✦ LIBER ✦

Chromanol derivatives—A novel class of CETP inhibitors

✍ Scribed by Alexandros Vakalopoulos; Carsten Schmeck; Michael Thutewohl; Volkhart Li; Hilmar Bischoff; Klemens Lustig; Olaf Weber; Holger Paulsen; Harry Elias

Book ID: 104005060
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 305 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.10.110

No coin nor oath required. For personal study only.

✦ Synopsis

Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties suitable for clinical studies. Chemical process optimization furnished a robust synthesis for a kilogram-scale process.

📜 SIMILAR VOLUMES

Design of a novel class of biphenyl CETP

Design of a novel class of biphenyl CETP inhibitors

✍ Zhijian Lu; Joann B. Napolitano; Ashleigh Theberge; Amjad Ali; Milton L. Hammond 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 468 KB

A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.

Dibenzodioxocinones—A new class of CETP

Dibenzodioxocinones—A new class of CETP inhibitors

✍ David Brückner; Frank-Thorsten Hafner; Volkhart Li; Carsten Schmeck; Joachim Tel 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 236 KB

Quinoxalinylurea Derivatives as a Novel

Quinoxalinylurea Derivatives as a Novel Class of JSP-1 Inhibitors.

✍ Li Zhang; Beiying Qiu; Bing Xiong; Xin Li; Jingya Li; Xin Wang; Jia Li; Jingkang 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 19 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Phosphonosuccinic acid derivatives: A no

Phosphonosuccinic acid derivatives: A novel class of bone resorption inhibitors

✍ Esswein, A.; Tsaklakidis, C.; Bauss, F.; uenther, H.; Muehlbauer, R.; Fleisch, H 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 141 KB

ChemInform Abstract: Isatin Derivatives,

ChemInform Abstract: Isatin Derivatives, a Novel Class of Transthyretin Fibrillogenesis Inhibitors.

✍ Asensio Gonzalez; Josefina Quirante; Joan Nieto; Maria Rosario Almeida; Maria Jo 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 16 KB 👁 1 views

Oxa-azaspiro Derivatives: a Novel Class

Oxa-azaspiro Derivatives: a Novel Class of Triple Re-uptake Inhibitors

✍ Michela Bettati; Paolo Cavanni; Romano Di Fabio; Beatrice Oliosi; Ornella Perini 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB

Drugs able to interfere with either the uptake or the metabolism of endogenous monoamines have been used for many years to treat depression. The first drugs of this type, such as the monoamine oxidase (MAO) inhibitors and the tricyclic antidepressants, achieved wide diffusion in the market, but are