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Design of a novel class of biphenyl CETP inhibitors

✍ Scribed by Zhijian Lu; Joann B. Napolitano; Ashleigh Theberge; Amjad Ali; Milton L. Hammond; Eugene Tan; Xinchun Tong; Suoyu S. Xu; Melanie J. Latham; Laurence B. Peterson; Matt S. Anderson; Suzanne S. Eveland; Qiu Guo; Sheryl A. Hyland; Denise P. Milot; Ying Chen; Carl P. Sparrow; Samuel D. Wright; Peter J. Sinclair

Book ID: 104004988
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 468 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.10.019

No coin nor oath required. For personal study only.

✦ Synopsis

A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.

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