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Phosphonosuccinic acid derivatives: A novel class of bone resorption inhibitors

✍ Scribed by Esswein, A.; Tsaklakidis, C.; Bauss, F.; uenther, H.; Muehlbauer, R.; Fleisch, H.; Bosies, E.

Book ID
123306385
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
141 KB
Volume
17
Category
Article
ISSN
8756-3282

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Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties s