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Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene

✍ Scribed by Mihai D. Niculescu; Yutaka Yamamuro; Steven H. Zeisel


Book ID
111178239
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
339 KB
Volume
89
Category
Article
ISSN
0022-3042

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## Background: D-type cyclins, in association with the cyclin-dependent kinases cdk4 and cdk6, promote progression through the g1 phase of the cell cycle. cdk activity is modulated by inhibitors such as p15ink4b and p16ink4a. loss of function of p15ink4b and p16ink4a (multiple tumor suppressor-i an