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Cholic Acid Derivatives as 1,2,4,5-Tetraoxane Carriers: Structure and Antimalarial and Antiproliferative Activity 1,†

✍ Scribed by Opsenica, Dejan; Pocsfalvi, Gabriela; Juranić, Zorica; Tinant, Bernard; Declercq, Jean-Paul; Kyle, Dennis E.; Milhous, Wilbur K.; Šolaja, Bogdan A.

Book ID
121439677
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
144 KB
Volume
43
Category
Article
ISSN
0022-2623

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An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-