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Chitosan-graft-spermine as a gene carrier in vitro and in vivo

✍ Scribed by Hu-Lin Jiang; Hwang-Tae Lim; You-Kyoung Kim; Rohidas Arote; Ji-Young Shin; Jung-Taek Kwon; Ji-Eun Kim; Ji-Hye Kim; Duyeol Kim; Chanhee Chae; Jae-Woon Nah; Yun-Jaie Choi; Chong-Su Cho; Myung-Haing Cho


Book ID
116438371
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
886 KB
Volume
77
Category
Article
ISSN
0939-6411

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We explored poly(4-vinylimidazole) (P4V) as a nonviral gene carrier. We show that P4V can form DNA condensates of small size (<110 nm) using a dye-exclusion assay with ethidium bromide and dynamic light scattering, and that the complexes form in a pHsensitive manner, due to the amphotericity of the