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In vitro and in vivo gene delivery using polyethylenimine-poly(hydroxyethyl glutamine) as a non-viral carrier

✍ Scribed by Jie Chen; Huayu Tian; Arihiro Kano; Atsushi Maruyama; Xuesi Chen; Tae Gwan Park


Book ID
113694758
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
629 KB
Volume
152
Category
Article
ISSN
0168-3659

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Poly (4-vinylimidazole) as nonviral gene
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We explored poly(4-vinylimidazole) (P4V) as a nonviral gene carrier. We show that P4V can form DNA condensates of small size (<110 nm) using a dye-exclusion assay with ethidium bromide and dynamic light scattering, and that the complexes form in a pHsensitive manner, due to the amphotericity of the