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Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo

✍ Scribed by Köping-Höggård, M; Tubulekas, I; Guan, H; Edwards, K; Nilsson, M; Vårum, K M; Artursson, P

Book ID: 110038954
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 882 KB
Volume: 8
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3301492

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## Abstract ## Background Chitosans of high molecular weights have emerged as efficient nonviral gene delivery systems, but the properties and efficiency of well‐defined low molecular weight chitosans (<5 kDa) have not been studied. We therefore characterized DNA complexes of such low molecular we