Chiral separations of basic drugs and quantitation of bupivacaine enantiomers in serum by capillary electrophoresis with modified cyclodextrin buffers
β Scribed by Helena Soini; Marja-Liisa Riekkola; Milos V. Novotny
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 788 KB
- Volume
- 608
- Category
- Article
- ISSN
- 1873-3778
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π SIMILAR VOLUMES
## Abstract The influence of seven differently methylated Ξ²βcyclodextrin derivatives and of pure Ξ²βcyclodextrin (Ξ²βCD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much mor
The influence of the choice of type and/or concentration of cyclodextrin, other additives, the temperature surrounding the capillary, and buffer pH on the separation of some chiral basic drug substances in capillary zone electrophoresis has been evaluated. It was found that pH of the buffer and type