## Abstract The influence of seven differently methylated β‐cyclodextrin derivatives and of pure β‐cyclodextrin (β‐CD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much mor
Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors
✍ Scribed by Nina Grobuschek; Lawan Sriphong; Martin G Schmid; Tamàs Lorànd; Hassan Y Aboul-Enein; Gerald Gübitz
- Book ID
- 117331229
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 129 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0165-022X
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## Abstract High resolution could be achieved for the enantiomers of acidic drugs, namely, sulindac, fenoprofen, ketoprofen, warfarin, and hexobarbital, in a buffer of pH 3 by the simultaneous addition of uncharged and charged β‐cyclodextrin derivatives. The interaction of the analytes with the ani
## Abstract This paper deals with the use of Cu(II) complexes of L‐tartaric acid or L‐threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand‐exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and β‐blockers were resolve