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Chiral separation of sympathomimetics and β-blockers by ligand-exchange CE using Cu(II) complexes of L-tartaric acid and L-threonine as chiral selectors

✍ Scribed by Heike Hödl; Axel Krainer; Katja Holzmüller; Julia Koidl; Martin G. Schmid; Gerald Gübitz

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 399 KB
Volume: 28
Category: Article
ISSN: 0173-0835
DOI: 10.1002/elps.200600825

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✦ Synopsis

Abstract

This paper deals with the use of Cu(II) complexes of L‐tartaric acid or L‐threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand‐exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and β‐blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12.

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