Enantioseparations of dansyl amino acids by capillary electrophoresis using Cu(II) complexes with L-amino acylamides as chiral selectors in electrolytes

✍ Scribed by Zilin Chen; Megumi Niitsuma; Tatsuro Nakagama; Katsumi Uchiyama; Toshiyuki Hobo

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 236 KB
• Volume: 25
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/1615-9314(20021101)25:15/17<1197::aid-jssc1197>3.0.co;2-2

✦ Synopsis

Enantioseparations of dansyl amino acids by capillary electrophoresis using Cu(II) complexes with L-amino acylamides as chiral selectors in electrolytes

Enantioseparations of dansyl amino acids using Cu(II) complexes with L-amino acylamides as the chiral selectors in the electrolyte solution were investigated by capillary electrophoresis. It has been demonstrated that the Cu(II) complexes with L-amino acylamides such as L-phenylalaninamide, L-prolinamide, and L-alaninamide are suitable for use as chiral selectors for enantioseparations of dansyl amino acids. The optimal separation conditions were examined. The employed chiral ligands exhibited different enantioselectivities and enantiomer migration orders. The enantiomer migration orders are discussed by using three different chiral selectors. L-enantiomers migrate faster than D-enantiomers when Cu(II)-L-phenylalaninamide and Cu(II)-Lalaninamide are used as chiral selectors, but D-enantiomers faster than their L-counterparts in the Cu(II)-L-prolinamide system.