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Chiral induction in aryl radical cyclisations

โœ Scribed by Keith Jones; Clive McCarthy

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
242 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Ortho-haloacryloylanilides

carrying chiral auxiliaries on the nitrogen undergo radical cyclisation to give oxindoles in optical yields up to 39%.

We have recently described the synthesis of 3-substituted, 3,3_disubstituted, and 3,3spirooxindoles via cyclisation of the aryl radicals derived from o-bromoacryloylanilidesl.

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