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Chiral analysis of basic drugs by oligosaccharide-mediated capillary electrophoresis

✍ Scribed by A. D'Hulst; N. Verbeke

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
775 KB
Volume
735
Category
Article
ISSN
1873-3778

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## Abstract The influence of seven differently methylated β‐cyclodextrin derivatives and of pure β‐cyclodextrin (β‐CD) on the enantiomeric resolution by capillary electrophoresis of six basic chiral pharmaceuticals is investigated. The methyl substitution pattern affects enantioselectivity much mor

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The influence of the choice of type and/or concentration of cyclodextrin, other additives, the temperature surrounding the capillary, and buffer pH on the separation of some chiral basic drug substances in capillary zone electrophoresis has been evaluated. It was found that pH of the buffer and type