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Chimeric RNA/DNA oligonucleotide-based gene therapy

✍ Scribed by Lai, Li-Wen; Lien, Yeong-Hau H.

Book ID
104474667
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
95 KB
Volume
61
Category
Article
ISSN
0085-2538

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This paper deals with the synthesis of m 3 2,2,7 G 5% pppAmpUmpApd(CpTpTpApCpCpT), a 5%-TMG-capped RNA-DNA chimeric oligonucleotide, which is expected to be conveyed to the nucleus by snurportin 1, a nuclear-transport protein. This 5%-TMG-capped RNA-DNA chimeric molecule was synthesized by the enzym