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In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides

✍ Scribed by Kren, Betsy T.; Bandyopadhyay, Paramita; Steer, Clifford J.


Book ID
109927738
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
904 KB
Volume
4
Category
Article
ISSN
1078-8956

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Targeted nucleotide exchange in the alka
✍ B T Kren; A Cole-Strauss; E B Kmiec; C J Steer πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 597 KB

Although a variety of methods has been devised for modification of hepatic genes, none has been effective for long-term correction of genetic disorders. In this study, we employed a recently described novel experimental strategy for site-directed nucleotide exchange in genomic DNA of HuH-7 human hep