Jacobsen's kinetic resolution, Sharpless epoxidation, Stille-Gennari, and Yamaguchi lactonization as key reactions.
Chemoenzymatic total synthesis of stagonolide-E
โ Scribed by Tapas Das; Samik Nanda
- Book ID
- 113930295
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 233 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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## Abstract A simple asymmetric total synthesis of stagonolide G (**1**) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl __Grignard__ reactions are involved in generating the stereogenic centers C(4) and C(8), followed by __GrubbsโIIโ__catalyzed ringโclosing
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