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Asymmetric Total Synthesis of Stagonolide G

✍ Scribed by Dasari Ramesh; Singanaboina Rajaram; Peddikotla Prabhakar; Udugu Ramulu; Dorigondla Kumar Reddy; Yenamandra Venkateswarlu

Book ID
102257562
Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
159 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A simple asymmetric total synthesis of stagonolide G (1) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by __Grubbs‐II‐__catalyzed ring‐closing metathesis (RCM).

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