ChemInform Abstract: Zinc-Catalyzed Chemoselective Reduction of Tertiary and Secondary Amides to Amines.
β Scribed by Shoubhik Das; Daniele Addis; Kathrin Junge; Matthias Beller
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 50 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Selective Reduction of Secondary Amides to Amines in the Presence of Tertiary Amides. -The transformation is achieved by reduction of secondary amide moieties bearing an activating Cbz group with hydrides. Catalytic hydrogenation of the resulting hemiacetals removes the hydroxyl and the Cbz group t
## Abstract The chemoselective transformation of secondary amides to imines, amines, or aldehydes is achieved under metalβfree conditions.
## Abstract A wide range of aromatic and aliphatic esters smoothly undergoes Znβcatalyzed reduction in the presence of SiHMe(OβEt)~2~ to give the corresponding alcohols in good yields.
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