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ChemInform Abstract: Controlled and Chemoselective Reduction of Secondary Amides.

✍ Scribed by Guillaume Pelletier; William S. Bechara; Andre B. Charette


Publisher
John Wiley and Sons
Year
2011
Weight
50 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

The chemoselective transformation of secondary amides to imines, amines, or aldehydes is achieved under metal‐free conditions.


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Selective Reduction of Secondary Amides to Amines in the Presence of Tertiary Amides. -The transformation is achieved by reduction of secondary amide moieties bearing an activating Cbz group with hydrides. Catalytic hydrogenation of the resulting hemiacetals removes the hydroxyl and the Cbz group t

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v