## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
ChemInform Abstract: Total Synthesis of (.+-.)-Calanolide A.
β Scribed by K. S. REHDER; J. A. KEPLER
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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A Catalytic Enantioselective Approach to Chromans and Chromanols. A Total Synthesis of (-)-Calanolides A (IX) and B (VIII) and the Vitamin E Nucleus (XIII). -The key steps in the synthesis of the title compounds are regio-and enantioselective allylic alkylation of phenols and subsequent ring closure
12-3H]-(+)-Calanolide A (9) was synthesized in five steps from readily available phloroglucinol (1). Stereoselective Luche reduction of transketone 8 with cerium(ll1) chloride and sodium borotritide in methanol gave 338 pCi of 9 with a specific activity of 63.0 mCi/mmol.
Total Synthesis of (-)-Epothilone A. -A key step in the synthesis of the title antitumor natural product is the highly stereoselective aldol reaction of the optically active building blocks (I) and (II). Esterification of the product (IV) with the subunit (V) leads to the stereochemically homogeneou