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ChemInform Abstract: The Total Synthesis of Scytophycin C. Part 2. Synthesis of Scytophycin C from the Protected Seco Acid.

โœ Scribed by I. PATERSON; C. WATSON; K.-S. YEUNG; R. A. WARD; P. A. WALLACE


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: The Total Synthesis
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The Total Synthesis of Scytophycin C. Part 1. Stereocontrolled Synthesis of the C 1 -C 32 Protected Seco Acid. -A stereocontrolled preparation of the C 1 -C 32 -seco acid ester (XI) required for the total synthesis of the macrolide scytophycin C is presented starting from the aldehyde (S)-(II) in 1

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Studies Directed Toward the Total Synthesis of Scytophycin C: Synthesis of the C 1 -C 18 Fragment of Scytophycin C. -The synthesis of the C-1 to C-18 fragment (X) is based on a highly stereoselective carbon Ferrier-type rearrangement reaction of deoxyglucal (I) and the silyl enol ether (II). -(GRIEC

ChemInform Abstract: Synthesis of the C1
โœ P. A. GRIECO; J. D. SPEAKE; S. K. YEO; M. MIYASHITA ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 38 KB

Synthesis of the C 19 -C 32 Fragment of Scytophycin C via Stereospecific Methylation of ฮณ,ฮด-Epoxy Acrylates with Trimethylaluminum. -The synthesis of the title compound features an iterative, stereospecific methylation of ฮณ,ฮด-epoxy acrylates (II) and (V) by trimethylaluminum in the presence of an ex