The 2R and 2S-endo isomers of N6-(5,6-epoxynorbom-2-yl)adenosine have been synthesised and shown to be potent agonists for the AI adenosine receptor. The 2S-endo isomer was equipotent to N 6cyclopentyladenosine and 10-to 12-fold more potent than the 2R-endo isomer.
ChemInform Abstract: The Design and Synthesis of Novel Adenosine Agonists.
β Scribed by P. J. SCAMMELLS; S. P. BAKER; L. BELLARDINELLI; R. A. OLSSON; R. A. RUSSELL; S. A. KNEVITT
- Book ID
- 112036735
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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