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The design and synthesis of novel adenosine agonists

✍ Scribed by P.J. Scammells; S.P. Baker; L. Bellardinelli; R.A. Olsson; R.A. Russell; S.A. Knevitt

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 244 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00111-4

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✦ Synopsis

The 2R and 2S-endo isomers of N6-(5,6-epoxynorbom-2-yl)adenosine have been synthesised and shown to be potent agonists for the AI adenosine receptor. The 2S-endo isomer was equipotent to N 6cyclopentyladenosine and 10-to 12-fold more potent than the 2R-endo isomer.

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