The 2R and 2S-endo isomers of N6-(5,6-epoxynorbom-2-yl)adenosine have been synthesised and shown to be potent agonists for the AI adenosine receptor. The 2S-endo isomer was equipotent to N 6cyclopentyladenosine and 10-to 12-fold more potent than the 2R-endo isomer.
The synthesis of the novel adenosine agonists, exo- and endo- N6-(5,6-epoxynorborn-2-yl)adenosine
โ Scribed by Peter J. Scammells; Stephen P. Baker; Luiz Bellardinelli; Ray A. Olsson; Richard A. Russell; Denis M.J. Wright
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 594 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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