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Design, Synthesis, and Evaluation of Novel A 2A Adenosine Receptor Agonists

โœ Scribed by Rieger, Jayson M.; Brown, Milton L.; Sullivan, Gail W.; Linden, Joel; Macdonald, Timothy L.


Book ID
120313835
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
314 KB
Volume
44
Category
Article
ISSN
0022-2623

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The design and synthesis of novel adenos
โœ P.J. Scammells; S.P. Baker; L. Bellardinelli; R.A. Olsson; R.A. Russell; S.A. Kn ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 244 KB

The 2R and 2S-endo isomers of N6-(5,6-epoxynorbom-2-yl)adenosine have been synthesised and shown to be potent agonists for the AI adenosine receptor. The 2S-endo isomer was equipotent to N 6cyclopentyladenosine and 10-to 12-fold more potent than the 2R-endo isomer.