The DE Novo Design and Synthesis of Cyclic Urea Inhibitors of Factor Xa: Initial SAR Studies. -A series of cyclic ureas is prepared and tested as inhibitors of the blood coagulation protein factor Xa. Molecular modelling calculations are performed to study the docking of the compounds to the factor
ChemInform Abstract: The De Novo Design and Synthesis of Cyclic Urea Inhibitors of Factor Xa: Optimization of the S4 Ligand.
β Scribed by Robert A. Galemmo Jr.; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable via the βReferencesβ option.
π SIMILAR VOLUMES
The Synthesis and Evaluation of Cyclic Ureas as HIV Protease Inhibitors: Modifications of the P1/P1' Residues. -Among various novel cyclic ureas compounds (VIII) show improved antiviral activity against HIV compared with the lead compounds DMP 323 and DMP 450. -(PATEL,