Tetrazole-substituted ureas as inhibitor
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Claude F Purchase II; Andrew D White; Maureen K Anderson; Thomas M.A Bocan; Rich
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Article
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1996
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Elsevier Science
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English
β 327 KB
A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently inhibit liver ACAT in vitro and lower total serum cholesterol in vivo. A comparison of urea 2b and the anti-atherosclerotic CI-976 in a long-ter