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ChemInform Abstract: Tetrazole-Substituted Ureas as Inhibitors of Acyl-CoA:Cholesterol O- Acyltransferase (ACAT). A Novel Preparation of Ureas from Weakly Nucleophilic Amines.

✍ Scribed by C. F. II PURCHASE; A. D. WHITE; M. K. ANDERSON; T. M. A. BOCAN; R. F. BOUSLEY; K. L. HAMELEHLE; R. HOMAN; B. R. KRAUSE; P. LEE; S. B. MUELLER; C. SPEYER; R. L. STANFIELD; J. F. REINDEL


Book ID
112041045
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
27
Category
Article
ISSN
0931-7597

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Tetrazole-substituted ureas as inhibitor
✍ Claude F Purchase II; Andrew D White; Maureen K Anderson; Thomas M.A Bocan; Rich πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 327 KB

A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently inhibit liver ACAT in vitro and lower total serum cholesterol in vivo. A comparison of urea 2b and the anti-atherosclerotic CI-976 in a long-ter