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ChemInform Abstract: Synthesis and Transformations of Hydrazine Substituted 6-Fluoro Derivatives of 1,3,4-Thiadiazolo[3,2-a]pyrimidine.

✍ Scribed by Muhamadsho A. Kukaniev; Cyril Parkanyi


Book ID
112043186
Publisher
John Wiley and Sons
Year
2012
Weight
31 KB
Volume
43
Category
Article
ISSN
0931-7597

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## Abstract 2‐Alkyl and 2‐arylhydrazine derivatives of 5__H__‐2‐R‐6‐fluoro‐7‐methyl‐1,3,4‐thiadiazolo[3,2‐__a__]pyrimidin‐5‐one were prepared by reaction of 5__H__‐2‐bromo‐6‐fluoro‐7‐methyl‐1,3,4‐thiadiazolo[3,2‐__a__]pyrimidin‐5‐one with hydrazine derivatives. A convenient procedure was developed

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## Abstract 2‐Alkyl‐, 2‐aryl‐, and 2‐halo‐substituted derivatives of 7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo[3,2‐__a__]pyrimidin‐6‐one (**3**) were prepared by reaction of 2‐substituted 5‐amino‐1,3,4‐thiadiazoles (**1**) and ethyl 2‐fluoroacetoacetate (**2**) in polyphosphoric acid. A convenient proced

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

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Synthesis of 1,2,3-Thiadiazolo (5,4-d)pyrimidines. -Condensation of 5-aminothiadiazole-4-carboxamides (I) or (IV) with orthoesters provides the target thiadiazolopyrimidines in moderate to good yield. Attempts to synthesize this heterocyclic system by three-component condensation of readily availab