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Synthesis and conversion of 6-fluoro derivatives of 1,3,4-thiadiazolo-[3,2-a]pyrimidine

✍ Scribed by Muhamadsho A. Kukaniev; Cyril Párkányi

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
86 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

2‐Alkyl‐, 2‐aryl‐, and 2‐halo‐substituted derivatives of 7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐6‐one (3) were prepared by reaction of 2‐substituted 5‐amino‐1,3,4‐thiadiazoles (1) and ethyl 2‐fluoroacetoacetate (2) in polyphosphoric acid. A convenient procedure was developed for the synthesis of new 2‐amino derivatives of 2‐R‐7‐methyl‐6‐fluoro‐1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐6‐one (5). J. Heterocyclic Chem., (2011).

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