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ChemInform Abstract: Synthesis and in vitro Evaluation of the Farnesyltransferase Inhibitor Pepticinnamin E.

✍ Scribed by Klaus Hinterding; Patrizia Hagenbuch; Janos Retey; Herbert Waldmann

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
30
Category
Article
ISSN
0931-7597

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Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact