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ChemInform Abstract: Synthesis and in vitro Evaluation of Novel Highly Potent Coumarin Inhibitors of Gyrase B.

✍ Scribed by Patrick Laurin; Didier Ferroud; Michel Klich; Claudine Dupuis-Hamelin; Pascale Mauvais; Patrice Lassaigne; Alain Bonnefoy; Branislav Musicki


Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Design, Synthesis a
✍ Andrian Folkes; et al. et al. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 28 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Synthesis and in vi
✍ L. C. CREEMER; H. A. KIRST; C. J. VLAHOS; R. M. SCHULTZ πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 1 views

title esters, e.g. (Ib)-(Ie), are synthesized by deacetylation and subsequent reacylation of wortmannin (Ia). In comparison with the latter one, they show superior inhibition of phosphatidylinositol (PI) 3-kinase and increased cell cytotoxicity in vitro. Reduction of (Ib) to (IIa) slightly enhances