Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib). -Claisen condensation, followed by regioselective reaction with the hydrochloride
β¦ LIBER β¦
ChemInform Abstract: Synthesis and Biological Evaluation of the Pyrazole Class Cyclooxygenase-2-Inhibitors.
β Scribed by Samia M. Rida; Manal N. S. Saudi; Amal M. Youssef; Madiha A. Halim
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 34 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
ChemInform Abstract: Synthesis and Biolo
β
T. D. PENNING; J. J. TALLAY; S. R. BERTENSHAW; J. S. CARTER; P. W. COLLINS; S. D
π
Article
π
2010
π
John Wiley and Sons
β 35 KB
π 1 views
ChemInform Abstract: Synthesis and Biolo
β
Maria I. Crespo; et al. et al.
π
Article
π
2010
π
John Wiley and Sons
β 29 KB
π 1 views
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
ChemInform Abstract: Synthesis and Biolo
β
Joan Bosch; Tomas Roca; Juan-Lorenzo Catena; Oriol Llorens; Juan-Jesus Perez; Ca
π
Article
π
2000
π
John Wiley and Sons
β 31 KB
π 1 views
ChemInform Abstract: Syntheses and Biolo
β
S. Oelgen; E. Guener; M. A. Fabregat; M. I. Crespo; D. Nebioglu
π
Article
π
2010
π
John Wiley and Sons
β 33 KB
π 2 views
ChemInform Abstract: Synthesis and Evalu
ChemInform Abstract: Synthesis and Evaluation of Dithiolethiones as Novel Cyclooxygenase Inhibitors.
β
Shannon D. Zanatta; David T. Manallack; Bevyn Jarrott; Spencer J. Williams
π
Article
π
2009
π
John Wiley and Sons
β 26 KB
π 1 views
ChemInform Abstract: Design, Synthesis,
β
Bo Jiang; Yi Zeng; Meng-Jie Li; Jin-Yi Xu; Yong-Na Zhang; Qiu-Juan Wang; Ni-Yue
π
Article
π
2010
π
John Wiley and Sons
β 24 KB
## Abstract The results of biological tests show that compound (I) is a potent and selective inhibitor of COXβ2 (IC~50~ = 0.37 ΞΌM) being equipotent to celecoxib.