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ChemInform Abstract: Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib).

✍ Scribed by T. D. PENNING; J. J. TALLAY; S. R. BERTENSHAW; J. S. CARTER; P. W. COLLINS; S. DOCTER; M. J. GRANETO; L. F. LEE; J. W. MALECHA; J. M. MIYASHIRO; ET AL. ET AL.

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib).

-Claisen condensation, followed by regioselective reaction with the hydrochloride of arylhydrazines yields almost exclusively 1,5-diarylpyrazoles. Among a series of derivatives, e.g. (I), (II), and ( III), only title compound (Ib) is of interest for further evaluation in clinical trials concerning treatment of rheumatoid arthritis and osteoarthritis. -(PENNING, T. D.;

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v