𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of a Library of 1-(2-Thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides.

✍ Scribed by Bridget A. Donohue; Enrique L. Michelotti; John C. Reader; Valerie Reader; Matthew Stirling; Colin M. Tice

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
33
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Biolo
ChemInform Abstract: Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib).
✍ T. D. PENNING; J. J. TALLAY; S. R. BERTENSHAW; J. S. CARTER; P. W. COLLINS; S. D πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 35 KB

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib). -Claisen condensation, followed by regioselective reaction with the hydrochloride

ChemInform Abstract: Design, Synthesis,
ChemInform Abstract: Design, Synthesis, and Biological Evaluation of 1,5-Diaryl-1,2,4-triazole Derivatives as Selective Cyclooxygenase-2 Inhibitors.
✍ Bo Jiang; Yi Zeng; Meng-Jie Li; Jin-Yi Xu; Yong-Na Zhang; Qiu-Juan Wang; Ni-Yue πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 24 KB

## Abstract The results of biological tests show that compound (I) is a potent and selective inhibitor of COX‐2 (IC~50~ = 0.37 ΞΌM) being equipotent to celecoxib.