✦ LIBER ✦

ChemInform Abstract: Synthesis and Biological Evaluation of a Series of Quinazoline-2- carboxylic Acids and Quinazoline-2,4-diones as Glycine-NMDA Antagonists: A Pharmacophore Model Based Approach.

✍ Scribed by V. COLOTTA; D. CATARZI; F. VARANO; L. CECCHI; G. FILACCHIONI; A. GALLI; C. COSTAGLI

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199742194

No coin nor oath required. For personal study only.

✦ Synopsis

Synthesis and Biological Evaluation of a Series of Quinazoline-2carboxylic Acids and Quinazoline-2,4-diones as Glycine-NMDA Antagonists: A Pharmacophore Model Based Approach.

-Although the compounds studied contain all features required by the antagonist pharmacophore model, they only show poor affinity for glycine-NMDA receptor.

📜 SIMILAR VOLUMES

Synthesis and Biological Evaluation of a

Synthesis and Biological Evaluation of a Series of Quinazoline-2-carboxylic Acids and Quinazoline-2,4-diones as Glycine-NMDA Antagonists: A Pharmacophore Model Based Approach

✍ Vittoria Colotta; Daniela Catarzi; Flavia Varano; Lucia Cecchi; Guido Filacchion 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

The synthesis and glycine-NMDA binding activity of a series of quinazoline-2-carboxylic acids 1 and quinazoline-2,4-diones 2, containing all the essential and optional pharmacophoric descriptors required by a putative glycine antagonist model, are reported. The binding results show that only three o

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists.

✍ Satoru Azukizawa; Masayasu Kasai; Kenji Takahashi; Tomohiro Miike; Kazuyoshi Kun 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

ChemInform Abstract: Synthesis and Pharm

ChemInform Abstract: Synthesis and Pharmacological Characterization of a Conformationally Restrained Series of Indole-2-carboxylates [cf. (VI)] as in vivo Potent Glycine Antagonists.

✍ Romano Di Fabio; Gianluca Araldi; Davide Baraldi; Alfredo Cugola; Daniele Donati 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB

ChemInform Abstract: Synthesis, Biologic

ChemInform Abstract: Synthesis, Biological Evaluation and Molecular Docking of Novel Series of Spiro[(2h,3H)quinazoline-2,1′-cyclohexan]-4(1H)-one Derivatives as Antiinflammatory and Analgesic Agents.

✍ K. M. Amin; M. M. Kamel; M. M. Anwar; M. Khedr; Y. M. Syam 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

ChemInform Abstract: Synthesis, Biologic

ChemInform Abstract: Synthesis, Biological Evaluation, and Structure-Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2.

✍ M. LEHR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

1997 indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140 ## 49 -143 Synthesis, Biological Evaluation, and Structure-Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2. -All title compounds are synthesize

ChemInform Abstract: Simple and Convenie

ChemInform Abstract: Simple and Convenient Synthesis of 2,3,4,5-Tetrahydro-1,5-dioxopyrrolo[1,2-a]quinazoline-3a(1H)-carboxylic Acids in Multi-Gram Scale.

✍ Rustam T. Iminov; Anton V. Tverdokhlebov; Andrey A. Tolmachev; Yulian M. Voloven 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 23 KB 👁 1 views