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ChemInform Abstract: Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists.

✍ Scribed by Satoru Azukizawa; Masayasu Kasai; Kenji Takahashi; Tomohiro Miike; Kazuyoshi Kunishiro; Mamoru Kanda; Chisato Mukai; Hiroaki Shirahase

Publisher: John Wiley and Sons
Year: 2008
Weight: 30 KB
Volume: 39
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200834152

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Synthesis and Properties of Enaminoketohydrazides of 1,2,3,4-Tetrahydroisoquinoline Series. -Reaction of dioxopyrroloisoquinolines (I) with hydrazine proceeds at the lactam carbonyl group with subsequent pyrroledione ring opening to afford the enaminoketohydrazides (II). Compounds (II) are characte