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ChemInform Abstract: Synthesis and Biological Evaluation of 4-Chloro-3,5-dinitrobenzotrifluoride Analogues as Antileishmanial Agents.

✍ Scribed by Kevin K. Pitzer; Karl A. Werbovetz; James J. Brendle; John P. Scovill

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis

and Biological Evaluation of 4-Chloro-3,5dinitrobenzotrifluoride Analogues as Antileishmanial Agents.

-Investigation of 17 desnitro analogues of title compound chloralin in vitro against amastigote-like Leishmania donovani parasites shows that compound (If) possesses excellent in vitro activity. However, (Ie) and (If), when further evaluated against L. donovani amastigotes in a hamster model, do not show any in vivo activity. -(PITZER,

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