ChemInform Abstract: Synthesis and Evaluation of Hapalosin and Analogues as MDR-Reversing Agents.
โ Scribed by Celeste E. O'Connell; Kathleen A. Salvato; Zhaoyang Meng; Bruce A. Littlefield; C. Eric Schwartz
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Synthesis and Conformational Analysis of the Multidrug Resistance-Reversing Agent Hapalosin (XIIIa) and Its Non-N-methyl Analogue (XIIIb) . -The key steps in the synthesis of (XIIIa) include two Brown allylboration reactions to obtain the chiral precursors (II) and (V) and macrolactonization of the
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