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ChemInform Abstract: Syntheses of Novel Pyrazolomorphinans and Their Binding to μ- and χ-Opioid-receptors.

✍ Scribed by I. STROETMANN; G. SEITZ; K. T. WANNER; G. HOEFNER

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Syntheses of Novel Pyrazolomorphinans and Their Binding to µand χ-Opioid-receptors.

-A number of novel pyrazolomorphinans [cf. (V)/(VI)] are synthesized by reaction of the enolic morphinan diketones (III) with hydrazines and evaluated for their affinity at µ and χ-opioid receptors in radioligand binding assays. All the tested compounds possess binding affinity for both the receptors comparable to that of codeine. -(STROET-

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