ChemInform Abstract: Synthesis and Opioid-Receptor Binding of Novel Amino-Substituted Morphan Analogues.
β Scribed by Georg Hoefner; Benedikt Streicher; Bernhard Wuensch
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Syntheses of Novel Pyrazolomorphinans and Their Binding to Β΅and Ο-Opioid-receptors. -A number of novel pyrazolomorphinans [cf. (V)/(VI)] are synthesized by reaction of the enolic morphinan diketones (III) with hydrazines and evaluated for their affinity at Β΅ and Ο-opioid receptors in radioligand bi