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ChemInform Abstract: Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity.

✍ Scribed by Yoshio Okada; Atsuko Fukumizu; Motohiro Takahashi; Toshio Yokoi; Yuko Tsuda; Sharon D. Bryant; Lawrence H. Lazarus


Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Syntheses of Novel
✍ I. STROETMANN; G. SEITZ; K. T. WANNER; G. HOEFNER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 35 KB

Syntheses of Novel Pyrazolomorphinans and Their Binding to Β΅and Ο‡-Opioid-receptors. -A number of novel pyrazolomorphinans [cf. (V)/(VI)] are synthesized by reaction of the enolic morphinan diketones (III) with hydrazines and evaluated for their affinity at Β΅ and Ο‡-opioid receptors in radioligand bi