✦ LIBER ✦

ChemInform Abstract: Syntheses of Novel Pyridazinomorphinans by Inverse Electron Demand Cycloaddition and Their Binding to μ and ϰ Receptors.

✍ Scribed by T. KLINDERT; I. STROETMANN; G. SEITZ; G. HOEFNER; K. TH. WANNER; G. FRENZEN; B. ECKHOFF

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199743248

No coin nor oath required. For personal study only.

✦ Synopsis

Syntheses of Novel Pyridazinomorphinans by Inverse Electron Demand Cycloaddition and Their Binding to µ and κ Receptors.

-The title reaction of various 3,6-disubstituted 1,2,4,5-tetrazines with enamines derived from dihydrocodeinone or codeinone gives the title compounds such as (I)-(IV). The structure of (IV) is established by X-ray crystallography. The binding affinity of (I)-(IV) is found to be lower than that of codeine. -(KLIN-

📜 SIMILAR VOLUMES

ChemInform Abstract: Syntheses of Novel

ChemInform Abstract: Syntheses of Novel Pyrazolomorphinans and Their Binding to μ- and χ-Opioid-receptors.

✍ I. STROETMANN; G. SEITZ; K. T. WANNER; G. HOEFNER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Syntheses of Novel Pyrazolomorphinans and Their Binding to µand χ-Opioid-receptors. -A number of novel pyrazolomorphinans [cf. (V)/(VI)] are synthesized by reaction of the enolic morphinan diketones (III) with hydrazines and evaluated for their affinity at µ and χ-opioid receptors in radioligand bi