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ChemInform Abstract: Stereoselective Synthesis of a 4a,9-Disubstituted Octahydroacridine from Isatin.

โœ Scribed by Hideki Abe; Yoshimi Sato; Kazuhiro Watanabe; Sakae Aoyagi; Chihiro Kibayashi; Tadashi Katoh

Publisher
John Wiley and Sons
Year
2009
Weight
23 KB
Volume
40
Category
Article
ISSN
0931-7597

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In order to prepare new tacrine-like compounds, the title compounds (VII), (X) and (XV) are synthesized. The synthetic pathway to (VII) represents a shorter and more suitable approach to prepare tacrine metabolites. An alternative route from (VIb) to compound (VIII), which exhibits very strong DNA b