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ChemInform Abstract: Stereoselective Synthesis of Enantiomerically Pure 4,5-Disubstituted Pyrrolidinones from β-Amino Esters.

✍ Scribed by Jianbo Wang; Yihua Hou; Peng Wu; Zhaohui Qu; Albert S. C. Chan

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
31
Category
Article
ISSN
0931-7597

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Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227. -The efficient synthesis of rac. (II) in a simple one-pot procedure was already described. A novel enzymatic resolution of its rac derivative