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ChemInform Abstract: Stereocontrolled Synthesis of the Fully Elaborated Aziridine Core of the Azinomycins.

✍ Scribed by R. S. COLEMAN; J.-S. KONG

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199831255

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✦ Synopsis

Stereocontrolled Synthesis of the Fully Elaborated Aziridine Core of the Azinomycins.

-The aziridino[1,2-a]pyrrolidine substructure of the antitumor agents Azinomycin A and B, isolated from Streptomyces griseofuscus, is synthesized from the key aldehyde (IV), which is obtained from (I) in 8 steps and 35% yield. -(COLEMAN, R.

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