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ChemInform Abstract: The Development of Strategies for Construction of the Aziridine Core of the Antitumor Agents Azinomycins A and B.

โœ Scribed by R. S. COLEMAN; A. J. CARPENTER

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

The Development of Strategies for Construction of the Aziridine Core of the Antitumor Agents Azinomycins A and B. -The key steps in the synthesis of the aziridine (VII) are Wadsworth-Horner-Emmons olefination to form the derivative (III), its bromination to the (E)-isomer (IV), and cyclization of the aziridine (VI). Unfortunately, removal of the Tbs-protecting group is difficult. -(COLEMAN, R. S.; CARPENTER, A.

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ChemInform Abstract: Stereocontrolled Sy
ChemInform Abstract: Stereocontrolled Synthesis of the Fully Elaborated Aziridine Core of the Azinomycins.
โœ R. S. COLEMAN; J.-S. KONG ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB

Stereocontrolled Synthesis of the Fully Elaborated Aziridine Core of the Azinomycins. -The aziridino[1,2-a]pyrrolidine substructure of the antitumor agents Azinomycin A and B, isolated from Streptomyces griseofuscus, is synthesized from the key aldehyde (IV), which is obtained from (I) in 8 steps a