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ChemInform Abstract: Novel Radical Synthesis of Morphine Fragments Spiro(benzofuran-3(2H),4′ -piperidine) and Octahydro-1H-benzofuro(3,2-e)isoquinoline.

✍ Scribed by C.-Y. CHENG; L.-W. HSIN; J.-P. LIOU

Book ID
112041364
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of morphine fragments spiro[be
Synthesis of morphine fragments spiro[benzofuran-3(2H),4′-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline by intramolecular Heck reaction
✍ Chen-Yu Cheng; Jing-Ping Liou; Mei-Jing Lee 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 209 KB

As a better alternative to radical cyclization, 5-(2-bromo-6-methoxyphenoxy)-2-methyl-l,2,3,4,5,6,7,8-octahydroisoquinoline (2) and its 1-oxo analog 3 underwent Pdcatalyzed intramolecular cyclization to give the tetracyclic (ACNO) morphine fragments 5 and 6 respectively. 4-[(2'-Iodo-6'-methoxyphenox