ChemInform Abstract: Nickel-Catalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride (Lithium Triethylborohydride).

✍ Scribed by Jingjing Wu; Song Cao

• Publisher: John Wiley and Sons
• Year: 2012
• Weight: 39 KB
• Volume: 43
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201213046

✦ Synopsis

Nickel-Catalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride (Lithium Triethylborohydride). -Two new catalyst systems are developed. Fluoroarenes and α,α,α-trifluorotoluene derivatives are reduced by the combination of 40 mol% NiCl2 and LiBHEt3 to afford the corresponding arenes and toluenes in excellent yields, whereas a catalytic amount of 5 mol% NiCl2(PCy3)2 in combination with LiBHEt 3 exhibits high activity and selectivity for fluoroarenes leaving C-F bonds of α,α,α-trifluorotoluene derivatives untouched. -(WU,