ChemInform Abstract: Modular Furanoside Phosphite Ligands for Asymmetric Pd-Catalyzed Allylic Substitution.
✍ Scribed by Oscar Pamies; Gino P. F. van Strijdonck; Montserrat Dieguez; Sirik Deerenberg; Gemma Net; Aurora Ruiz; Carmen Claver; Paul C. J. Kamer; Piet W. N. M. van Leeuwen
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A library of furanoside phosphite‐phosphoroamidite ligands has been synthesized and screened in the palladium‐catalyzed allylic substitution reactions of several substrate types. These series of ligands can be prepared efficiently from easily accessible D‐xylose and D‐glucose. Their mod
reactions of 1,3diphenyl-2-propenyl acetate (II). Best results are obtained with derivative (Ia). Dimethyl malonate as nucleophile gives the product (IV) with high e.e., whereas benzylamine provides only moderate stereoselectivity. -(JIN, MYUNG-